… each transgenic animal throughout the course of the disease. … during the postnatal
development we used sensitive μMRI and measurements of evoked potentials of the visual system (…

… shiverer mice, μMRI can discern hypomyelination throughout … and micro-MRI (μMRI) in
tandem on a dysmyelinating mouse … tract, part of the visual pathway along which the VEPs travel. …

… of the binocular visual cortex of anesthetized mice in response to … , even though these animals
display severe hypomyelination of … Outcome measures for trials of remyelinating agents in …

… of mouse genetics and the simplicity of the visual system to test … weighted microMRI images
at 6-minute intervals in an 11.7 T … Visual evoked potentials were measured before, and at 4 …

… An evoked response is an electrical potential recorded from … in an adult mouse visual
system characterized by modulation … temporal evolution of MS lesions with T 1 - and T 2 -weighted …

… /20 magnetic resonance microimaging system (… visual evoked potentials (fVEPs), a technique
that has been instrumental in identifying dysfunction of the optic system in hypomyelinating …

… the brain, such as the visual cortex and forebrain; and primary … In this transgenic mouse,
the J37 golli isoform is driven by a 1.9-… by increasing the size of these voltage-mediated Ca 2+ …

… of the brain, such as the visual cortex and forebrain. Impaired … they represent OLs at immature
stages of development. They … , and the intensities were measured within the same serial …

… microscope (Carl Zeiss MicroImaging). For quantification of the … The cerebellar weights of the
mutant mice were slightly lower … Hypomyelination of nerves in the brain and spinal cord was …

I hereby declare that I prepared the Ph. D. thesis" Cortical development and myelination in
the absence of Schizophrenia susceptibility gene Neuregulin1" on my own and with no other …